Santa Cruz Vacations from $288

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The Latest Santa Cruz vacation packages

Price found within the past 48 hours. Click for updated prices.
Gran Hotel Ipiales

Gran Hotel Ipiales

2 out of 5
Price was $298, price is now $288 per person
$288
per person
Jul 31 - Aug 3
found 1 day ago
Roundtrip non-stop flight included
Medellín (MDE) to Ipiales (IPI)
No reviews
Nogal Suite Hotel Ipiales

Nogal Suite Hotel Ipiales

3 out of 5
Price was $388, price is now $319 per person
$319
per person
Jul 31 - Aug 3
found 1 day ago
Roundtrip non-stop flight included
Medellín (MDE) to Ipiales (IPI)
7.8/10 Good! (19 reviews)
Doesn’t has a phone to connect with the reception, also there is not a xtra Lamp or light by the night table

Reviewed on Mar 11, 2026

Harmony Hotel

Harmony Hotel

2.5 out of 5
Price was $326, price is now $304 per person
$304
per person
Jul 31 - Aug 3
found 1 day ago
Roundtrip non-stop flight included
Medellín (MDE) to Ipiales (IPI)
9.4/10 Exceptional! (127 reviews)
Un lugar lindo limpio recomendable

Reviewed on Jun 4, 2026

Hotel Santa Isabel II

Hotel Santa Isabel II

3.5 out of 5
Price was $318, price is now $307 per person
$307
per person
Jul 31 - Aug 3
found 1 day ago
Roundtrip non-stop flight included
Medellín (MDE) to Ipiales (IPI)
8.6/10 Excellent! (8 reviews)
Parking was 1 block away but hotel provided a voucher so it was free parking. Only stayed one night before crossing boarder to Ecuador

Reviewed on Dec 1, 2025

Majestic Hotel

Majestic Hotel

3 out of 5
Price was $338, price is now $328 per person
$328
per person
Jul 31 - Aug 3
found 1 day ago
Roundtrip non-stop flight included
Medellín (MDE) to Ipiales (IPI)
10/10 Exceptional! (2 reviews)
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Santa Cruz Hotel Deals

Nogal Suite Hotel Ipiales

Nogal Suite Hotel Ipiales

3 out of 5
Cra. 7 #50 - 26, Barrio Puenes Ipiales Nariño
Fully refundableReserve now, pay when you stay
$50 nightly
The price is $50 total per night from Jun 29 to Jun 30
$50 total
Jun 29 - Jun 30
7.8/10 Good! (19 reviews)
"Doesn’t has a phone to connect with the reception, also there is not a xtra Lamp or light by the night table"

Reviewed on Mar 11, 2026

Nogal Suite Hotel Ipiales
Majestic Hotel

Majestic Hotel

3 out of 5
6-24 Cl. 24 Ipiales Nariño
Fully refundableReserve now, pay when you stay
$49 nightly
The price is $49 total per night from Jun 26 to Jun 27
$49 total
Jun 26 - Jun 27
10/10 Exceptional! (2 reviews)
"Si todo perfecto bien limpio todo habitación impecable buena atención del personal del hotel"

Reviewed on Jan 4, 2026

Majestic Hotel
Hotel Paraiso Real

Hotel Paraiso Real

2 out of 5
CALLE 17 CON CARRERA 9 Cumbal Nariño
$24 nightly
The price is $24 total per night from Jun 23 to Jun 24
$24 total
Jun 23 - Jun 24
Hotel Paraiso Real
See all 5 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Cruz Vacation Packages

Santa Cruz Essential Information

Language
Spanish
Currency
Colombian pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Ipiales (IPI-San Luis)

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Frequently asked questions

How much does a Santa Cruz vacation package cost?
Offering excellent value package deals from $288 on Expedia, you'll be surprised at how little a vacation to Santa Cruz costs! Our packages mean less travel planning for you and greater savings.
What are the cheapest months to go to Santa Cruz?
If you'd like to score a cheap Santa Cruz vacation package, consider planning a trip in March, April and May. You'll typically find lower prices on hotels and airfares during these months — perfect for a budget-friendly getaway.
How many days is enough for Santa Cruz?
Typically, a handful of days is enough to explore the main attractions during your Santa Cruz vacation. But if you want to have more time to relax or go on day trips, consider extending your trip.
How to find the best Santa Cruz package deals?
Begin your search for a Santa Cruz package deal by entering your destination and preferred travel dates under our "Packages" tab. Then select some filters, like "Property type" and "Popular locations," to fine-tune the results to your exact style. You can also sort by "Package discount" and discover offers that come with unbeatable savings. If you don't find the ideal Santa Cruz package deal right away, simply tweak your dates and search again. Keep in mind that deals are only available for a limited time, so book early and get your Santa Cruz adventure underway.
Is it cheaper to book a Santa Cruz vacation as a package?
Expedia vacation packages are designed to make your money go further. Bundle your flight, car rental and hotel into one great-value price and enjoy significant savings. You'll typically score a better deal than booking each component individually. And you'll still get the freedom to create a customized Santa Cruz vacation by choosing your preferred type of stay, airline and car class.
When to book a vacation package to Santa Cruz?
If you're considering a spontaneous Santa Cruz trip, browse our last-minute deals that can be booked up to one week before you take off. Don't want to leave things to the last minute? You can land awesome deals on your flights and hotels by booking well in advance.
Does Expedia offer Book Now, Pay Later Santa Cruz vacation packages?
Secure your dream getaway to Santa Cruz with help from our Book Now, Pay Later vacations. There's no need to scrimp and save or wait for your next paycheck — we've partnered with online lender Affirm to give you more flexibility with your finances. Our vacation packages with payment plans let you spread the cost over 3, 6 or 12 months. With no late payment fees or hidden charges, it's easy to stay on budget and snag great deals before they disappear.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.